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Rotigotine hydrochloride
CAS No. 125572-93-2
Rotigotine hydrochloride ( Rotigotine HCl )
产品货号. M11042 CAS No. 125572-93-2
A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥373 | 有现货 |
|
| 10MG | ￥535 | 有现货 |
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| 25MG | ￥794 | 有现货 |
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| 50MG | ￥1134 | 有现货 |
|
| 100MG | ￥1588 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Rotigotine hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor.
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产品描述A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor; behaves as a full agonist of D1, D2, and D3 with similar potencies (EC50) in functional assay; also demonstrates significant affinity at α-adrenergic (α2B, Ki=27 nM) and serotonin receptors (5-HT1A Ki=30 nM); significantly attenuates MPTP-induced acute cell degeneration in mouse model.Parkinson's Disease Approved
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同义词Rotigotine HCl
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通路GPCR/G Protein
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靶点Dopamine Receptor
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受体Dopamine Receptor
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研究领域Neurological Disease
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适应症Parkinson Disease
化学信息
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CAS Number125572-93-2
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分子量351.93
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分子式C19H26ClNOS
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O.Cl
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化学全称1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, hydrochloride (1:1), (6S)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
2. Scheller D, et al. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.
3. Scheller D, et al. Neurosci Lett. 2008 Feb 13;432(1):30-4.
产品手册
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